Independent travel site · All-in Pricing

Call
2.5-star hotel Pet friendly

Comfort Inn & Suites Sikeston I-55

109 Matthews Ln, Sikeston, MO
4.2
Very good 307 guest reviews
Add dates to see rooms and rates
Rates at this hotel change by night

Choose your room

Great valueLowest total
2 Queen Beds (1 of 4)
2 Queen Beds (2 of 4)
2 Queen Beds (3 of 4)
2 Queen Beds (4 of 4)
4 photos

2 Queen Beds

queen
  • Today's low rate
Rate needs datesTotals change by night
Standard rate
2 Queen Beds Accessible (1 of 4)
2 Queen Beds Accessible (2 of 4)
2 Queen Beds Accessible (3 of 4)
2 Queen Beds Accessible (4 of 4)
4 photos

2 Queen Beds Accessible

queen
Rate needs datesTotals change by night
Standard rate
1 King Bed (1 of 6)
1 King Bed (2 of 6)
1 King Bed (3 of 6)
1 King Bed (4 of 6)
1 King Bed (5 of 6)
1 King Bed (6 of 6)
6 photos

1 King Bed

king
Rate needs datesTotals change by night
Standard rate
1 King Bed Accessible (1 of 6)
1 King Bed Accessible (2 of 6)
1 King Bed Accessible (3 of 6)
1 King Bed Accessible (4 of 6)
1 King Bed Accessible (5 of 6)
1 King Bed Accessible (6 of 6)
6 photos

1 King Bed Accessible

king
Rate needs datesTotals change by night
Standard rate
1 King Bed Suite

1 King Bed Suite

suite
Rate needs datesTotals change by night
No dates yetRecently from $140 / night
All-in pricing The total you see is the total you pay.
Fast booking Search, compare, and book in seconds.
Secure checkout Encrypted payment, instant confirmation.
Help, 24/7 Real agents at +1 (833) 311-3855.

Where you'll be in Sikeston, MO

109 Matthews Ln, Sikeston, MO · 37.3 mi from Cape Girardeau Regional Airport (CGI)

Nearby

Cape Girardeau Regional Airport (CGI)
37.3 mi

What's included

All 22 amenities

Pool & Spa

  • Number of indoor pools - 1

Accessibility

  • Wheelchair accessible (may have limitations)
  • Wheelchair accessible parking
  • Elevator
  • Wheelchair-accessible registration desk

Property Services

  • Safe-deposit box at front desk
  • Laundry facilities
  • 24-hour front desk
  • Professional property host/manager

Parking & Transport

  • Free self parking

Things to Do

  • Fitness facilities

Business

  • Business center

Internet

  • Free WiFi

Pets

  • Maximum number of pets per room 2
  • Pet max weight (per pet) in lb is 20
  • Only dogs and cats are allowed
  • Pet max weight (per pet) in kg is 9
  • Service animals are allowed
  • Service animals are exempt from fees/restrictions
  • Pets allowed

Family

  • No cribs (infant beds) available
  • No rollaway/extra beds available

Property details

Check-in2:00 PM - anytime
Check-out11:00 AM
About Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55 is a 2.5-star Comfort Inns property in Sikeston, Missouri. The hotel sits just off Interstate 55, within a minute's drive of the City of Miner Convention Center and five minutes from the Sikeston Depot Museum.

The property offers free parking, a fitness center, a business center, and laundry facilities. A 24-hour front desk is available, and pets are welcome at the hotel.

The location is convenient for travelers visiting the Sikeston area or passing through on I-55. Cape Girardeau Regional Airport lies roughly 30 minutes away by car. The hotel is also near Central Park and within reasonable driving distance of the Mississippi River, making it practical for both business travelers and leisure visitors exploring southeast Missouri.

Guest rating breakdown
Cleanliness 4.2
Comfort 4.3
Service 4.4
Condition 4.1
Amenities 4.1
Location 4.5
Neighborhood 4.2
Value 2.5
Fees and extras
  • Pet fee: USD 20 per pet, per night Service animals are exempt from fees The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.
Check-in instructions
  • Extra-person charges may apply and vary depending on property policy
  • Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
  • Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
  • This property accepts credit cards; cash is not accepted
  • This property affirms that it follows the cleaning and disinfection practices of Commitment to Clean (Choice)
  • Front desk staff will greet guests on arrival at the property. Information provided by the property may be translated using automated translation tools.
Pet policy
  • Yes
Know before you go
  • This property allows pets in specific rooms only (surcharges apply and can be found in the Fees section). Guests can request one of these rooms by contacting the property directly, using the contact information on the booking confirmation.

Frequently asked questions

What are the check-in and check-out times?
Check-in starts at 2:00 PM - anytime. Check-out is by 11:00 AM.
Are taxes and fees included in the price?
Yes. Every total shown includes taxes and fees, and we never add a booking fee. Resort fees, where a hotel charges them, are collected at the property.
Is Comfort Inn & Suites Sikeston I-55 pet-friendly?
Yes — this property accepts pets. Charges and restrictions vary, so check the pet policy under Property details or call us before you book.
How far is the airport?
Cape Girardeau Regional Airport (CGI) is about 37.3 mi away.

Something else? Call us any time on +1 (833) 311-3855 .

Rooms from $140/night

Pick your dates for exact pricing and availability.

Choose your room Call +1 (833) 311-3855