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2.5-star hotel

Holiday Inn Express & Suites St. Louis South - I-55 by IHG

4250 Midamerica Lane, St. Louis, MO
4.8
Exceptional 1,000 guest reviews
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2 Queen Beds (1 of 20)
2 Queen Beds (2 of 20)
2 Queen Beds (3 of 20)
2 Queen Beds (4 of 20)
2 Queen Beds (5 of 20)
2 Queen Beds (6 of 20)
2 Queen Beds (7 of 20)
2 Queen Beds (8 of 20)
2 Queen Beds (9 of 20)
2 Queen Beds (10 of 20)
2 Queen Beds (11 of 20)
2 Queen Beds (12 of 20)
2 Queen Beds (13 of 20)
2 Queen Beds (14 of 20)
2 Queen Beds (15 of 20)
2 Queen Beds (16 of 20)
2 Queen Beds (17 of 20)
2 Queen Beds (18 of 20)
2 Queen Beds (19 of 20)
2 Queen Beds (20 of 20)
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2 Queen Beds

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1 King Bed Accessible (1 of 23)
1 King Bed Accessible (2 of 23)
1 King Bed Accessible (3 of 23)
1 King Bed Accessible (4 of 23)
1 King Bed Accessible (5 of 23)
1 King Bed Accessible (6 of 23)
1 King Bed Accessible (7 of 23)
1 King Bed Accessible (8 of 23)
1 King Bed Accessible (9 of 23)
1 King Bed Accessible (10 of 23)
1 King Bed Accessible (11 of 23)
1 King Bed Accessible (12 of 23)
1 King Bed Accessible (13 of 23)
1 King Bed Accessible (14 of 23)
1 King Bed Accessible (15 of 23)
1 King Bed Accessible (16 of 23)
1 King Bed Accessible (17 of 23)
1 King Bed Accessible (18 of 23)
1 King Bed Accessible (19 of 23)
1 King Bed Accessible (20 of 23)
1 King Bed Accessible (21 of 23)
1 King Bed Accessible (22 of 23)
1 King Bed Accessible (23 of 23)
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1 King Bed Accessible

king
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Quadruple Accessible Queen Size Bed (1 of 20)
Quadruple Accessible Queen Size Bed (2 of 20)
Quadruple Accessible Queen Size Bed (3 of 20)
Quadruple Accessible Queen Size Bed (4 of 20)
Quadruple Accessible Queen Size Bed (5 of 20)
Quadruple Accessible Queen Size Bed (6 of 20)
Quadruple Accessible Queen Size Bed (7 of 20)
Quadruple Accessible Queen Size Bed (8 of 20)
Quadruple Accessible Queen Size Bed (9 of 20)
Quadruple Accessible Queen Size Bed (10 of 20)
Quadruple Accessible Queen Size Bed (11 of 20)
Quadruple Accessible Queen Size Bed (12 of 20)
Quadruple Accessible Queen Size Bed (13 of 20)
Quadruple Accessible Queen Size Bed (14 of 20)
Quadruple Accessible Queen Size Bed (15 of 20)
Quadruple Accessible Queen Size Bed (16 of 20)
Quadruple Accessible Queen Size Bed (17 of 20)
Quadruple Accessible Queen Size Bed (18 of 20)
Quadruple Accessible Queen Size Bed (19 of 20)
Quadruple Accessible Queen Size Bed (20 of 20)
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Quadruple Accessible Queen Size Bed

queen
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Double Accessible

double
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1 Bedroom Suite Accessible (1 of 16)
1 Bedroom Suite Accessible (2 of 16)
1 Bedroom Suite Accessible (3 of 16)
1 Bedroom Suite Accessible (4 of 16)
1 Bedroom Suite Accessible (5 of 16)
1 Bedroom Suite Accessible (6 of 16)
1 Bedroom Suite Accessible (7 of 16)
1 Bedroom Suite Accessible (8 of 16)
1 Bedroom Suite Accessible (9 of 16)
1 Bedroom Suite Accessible (10 of 16)
1 Bedroom Suite Accessible (11 of 16)
1 Bedroom Suite Accessible (12 of 16)
1 Bedroom Suite Accessible (13 of 16)
1 Bedroom Suite Accessible (14 of 16)
1 Bedroom Suite Accessible (15 of 16)
1 Bedroom Suite Accessible (16 of 16)
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1 Bedroom Suite Accessible

suite
Rate needs datesTotals change by night
Standard rate
1 King Bed Suite (1 of 16)
1 King Bed Suite (2 of 16)
1 King Bed Suite (3 of 16)
1 King Bed Suite (4 of 16)
1 King Bed Suite (5 of 16)
1 King Bed Suite (6 of 16)
1 King Bed Suite (7 of 16)
1 King Bed Suite (8 of 16)
1 King Bed Suite (9 of 16)
1 King Bed Suite (10 of 16)
1 King Bed Suite (11 of 16)
1 King Bed Suite (12 of 16)
1 King Bed Suite (13 of 16)
1 King Bed Suite (14 of 16)
1 King Bed Suite (15 of 16)
1 King Bed Suite (16 of 16)
16 photos

1 King Bed Suite

suite
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Where you'll be in St. Louis, MO

4250 Midamerica Lane, St. Louis, MO

Nearby

St Anthonys Medical Center
5.6 mi
VA Medical Center St. Louis
6.4 mi
St Louis Developmental Center
6.5 mi
Grants Farm
6.8 mi
Ulysses S. Grant National Historic Site
7.2 mi
Laumeier Sculpture Park
9.2 mi
Powder Valley Nature Center
10.2 mi

What's included

All 35 amenities

Accessibility

  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible concierge desk
  • Wheelchair-accessible van parking
  • Wheelchair-accessible path to elevator
  • Wheelchair-accessible fitness center
  • Wheelchair-accessible pool
  • Wheelchair-accessible public washroom
  • Well-lit path to entrance
  • Stair-free path to entrance
  • Wheelchair accessible parking
  • Wheelchair-accessible lounge
  • Visual alarms in hallways
  • Elevator
  • Wheelchair accessible path of travel

Business

  • Banquet hall
  • Meeting rooms
  • Business center

Food & Drink

  • Vending machine
  • Free buffet breakfast
  • Free breakfast

Internet

  • Free WiFi

Property Services

  • Change of towels (on request)
  • 24-hour front desk
  • Housekeeping on request
  • Safe-deposit box at front desk
  • Professional property host/manager
  • LGBTQIA+ friendly

Pool & Spa

  • Number of indoor pools - 1
  • Pool sun loungers

Things to Do

  • 24-hour fitness facilities

Policies

  • Smoke-free property

Parking & Transport

  • Free self parking

Pets

  • Service animals are allowed
  • Service animals are exempt from fees/restrictions
  • Pets not allowed

Property details

Check-in3:00 PM - 2:30 AM
Check-out11:00 AM
About Holiday Inn Express & Suites St. Louis South - I-55 by IHG

Holiday Inn Express & Suites St. Louis South - I-55 by IHG is a 2.5-star property in St. Louis, part of the Holiday Inn Express chain. The hotel sits in the business district just south of the city center, positioned for easy access to both work and healthcare facilities in the area.

The property provides free breakfast daily, a business center for work needs, and a fitness center. A conference room is available for meetings, and the front desk operates 24 hours. All rooms are non-smoking. These basics make the hotel suitable for short stays and business travel without added cost or complication.

The location offers convenient proximity to St. Anthony's Medical Center, the VA Medical Center St. Louis, and the St. Louis Developmental Center. Barnes Jewish South Campus is a 5-minute drive away. Forest Park and the St. Louis Zoo lie 12–13 miles north. The I-55 access makes the hotel practical for visitors attending medical appointments or passing through St. Louis on the interstate corridor.

Guest rating breakdown
Cleanliness 4.8
Comfort 4.7
Service 4.8
Condition 4.8
Amenities 4.7
Neighborhood 4.9
Check-in instructions
  • Extra-person charges may apply and vary depending on property policy
  • Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
  • Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
  • This property accepts credit cards; cash is not accepted
  • Safety features at this property include a fire extinguisher
  • This property affirms that it follows the cleaning and disinfection practices of Clean Promise (IHG)
  • Front desk staff will greet guests on arrival at the property. Information provided by the property may be translated using automated translation tools.
Pet policy
  • No pets allowed, service animals ONLY
Know before you go
  • Pool access available from 8 AM to 10 PM.
  • The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.
  • Contactless check-out is available.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Frequently asked questions

What are the check-in and check-out times?
Check-in starts at 3:00 PM - 2:30 AM. Check-out is by 11:00 AM.
Are taxes and fees included in the price?
Yes. Every total shown includes taxes and fees, and we never add a booking fee. Resort fees, where a hotel charges them, are collected at the property.

Something else? Call us any time on +1 (833) 311-3855 .

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